Gedunin

• Supplier: Tocris Bioscience
• Catalog: 4453
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 2753-30-2
• Chemical Name: (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione
• Formula: C28H34O7
• Molecular Weight: 482.57
• Purity: >98 %
• Description: Naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC 50 values are 3.22, 8.84 and 16.8 μ M in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). Also exhibits antimalarial activity against P. falciparum (IC 50 values are 0.14 and 3.1 μ M in parasite development and [ 3 H]-hypoxanthine uptake assays respectively).

Product References

Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon - Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon

Uddin SJ, Nahar L, Shilpi JA, Shoeb M, Borkowski T, Gibbons S, Middleton M, Byres M, Sarker SD. Phytother Res. 2007 Aug;21(8):757-61.

Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary - Gedunin, a novel hsp90 inhibitor: semisynthesis of derivatives and preliminary

Brandt GE, Schmidt MD, Prisinzano TE, Blagg BS. J Med Chem. 2008 Oct 23;51(20):6495-502.

Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). - Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae).

Lee SE, Kim MR, Kim JH, Takeoka GR, Kim TW, Park BS. Phytomedicine. 2008 Jun;15(6-7):533-5. Epub 2007 Oct 29.