Geldanamycin

Name Geldanamycin
Supplier Tocris Bioscience
Catalog 3387
Prices $349.00
Sizes 1 mg
Cas Number 30562-34-6
Chemical Name 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione,9-carbamate
Formula C29H40N2O9
Molecular Weight 560.64
Purity >98 %
Description Selectively inhibits heat shock protein 90 (Hsp90). Binds to the ATP site of Hsp90 (K d = 1.2 μ M) and inhibits its chaperone activity. Consequently inhibits activities of oncogenic kinases (e.g. src, Raf), p53 and steroid receptors. Demonstrates antiproliferative effect on breast cancer stem-like cells.
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Product References

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation - Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation

Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8324-8.

Signal-transduction cascades as targets for therapeutic intervention by natural - Signal-transduction cascades as targets for therapeutic intervention by natural

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor - Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor

Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH. J Med Chem. 1999 Jan 28;42(2):260-6.

Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of - Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of

Lee CH, Hong HM, Chang YY, Chang WW. Biochimie. 2012 Jun;94(6):1382-9.