Gemcitabine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1368
• Prices: $109.00, $455.00
• Sizes: 10 mg, 50 mg
• Cas Number: 122111-03-9
• Chemical Name: (+)-2'-Deoxy-2',2'-difluorocytidinehydrochloride
• Formula: C9H11F2N3O4.HCl
• Molecular Weight: 299.66
• Purity: >99 %
• Description: Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo .

Product References

Evaluation of the antitumor activity of gemcitabine - Evaluation of the antitumor activity of gemcitabine

Hertel LW, Boder GB, Kroin JS, Rinzel SM, Poore GA, Todd GC, Grindey GB. Cancer Res. 1990 Jul 15;50(14):4417-22.

Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide - Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide

Heinemann V, Schulz L, Issels RD, Plunkett W. Semin Oncol. 1995 Aug;22(4 Suppl 11):11-8.

Preclinical characteristics of gemcitabine. - Preclinical characteristics of gemcitabine.

Plunkett W, Huang P, Gandhi V. Anticancer Drugs. 1995 Dec;6 Suppl 6:7-13.