Genistein

Name Genistein
Supplier Tocris Bioscience
Catalog 3259
Prices $59.00, $189.00
Sizes 10 mg, 50 mg
Cas Number 446-72-0
Chemical Name 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Formula C15H10O5
Molecular Weight 270.24
Purity >98 %
Description Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR γ and estrogen receptors and acts as an agonist at GPER. Also available as part of the MAPK Cascade Inhibitor Tocriset™ .
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Product References

Genistein, a specific inhibitor of tyrosine-specific protein kinases. - Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M, Fukami Y. J Biol Chem. 1987 Apr 25;262(12):5592-5.

Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor - Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor

Linassier C, Pierre M, Le Pecq JB, Pierre J. Biochem Pharmacol. 1990 Jan 1;39(1):187-93.

Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein - Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein

Migita K, Eguchi K, Kawabe Y, Mizokami A, Tsukada T, Nagataki S. J Immunol. 1994 Oct 15;153(8):3457-65.

Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular - Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular

Dang ZC, Audinot V, Papapoulos SE, Boutin JA, Lowik CW. J Biol Chem. 2003 Jan 10;278(2):962-7. Epub 2002 Nov 5.