GF 109203X

• Supplier: Tocris Bioscience
• Catalog: 1110
• Prices: $89.00, $189.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 133052-90-1
• Chemical Name: 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide
• Formula: C25H24N4O2
• Molecular Weight: 412.49
• Purity: >98 %
• Description: Very potent and selective inhibitor of protein kinase C, selective for the α and β 1 isoforms (IC 50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μ M for α , β 1, δ , ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC 50 values are 0.6, 4.6, and 33 μ M respectively). Potent antagonist at the 5-HT 3 receptor (K i = 29.5 nM). Anti-inflammatory in vivo .

Product References

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein - The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein

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Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. - Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976.

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Anti-inflammatory properties of Go 6850: a selective inhibitor of protein kinase - Anti-inflammatory properties of Go 6850: a selective inhibitor of protein kinase

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Competitive antagonism of the mouse 5-hydroxytryptamine3 receptor by - Competitive antagonism of the mouse 5-hydroxytryptamine3 receptor by

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Heat shock protein 90-mediated inactivation of nuclear factor-kappaB switches - Heat shock protein 90-mediated inactivation of nuclear factor-kappaB switches

Jiang Q, Wang Y, Li T, Shi K, Li Z, Ma Y, Li F, Luo H, Yang Y, Xu C. Mol Biol Cell. 2011 Apr 15;22(8):1167-80.