GGsTop

• Supplier: Tocris Bioscience
• Catalog: 0741
• Prices: $209.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 926281-37-0
• Chemical Name: 3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneaceticacid
• Formula: C13H18NO7P
• Molecular Weight: 331.26
• Purity: >98 %
• Description: Selective, irreversible γ -glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo .

Product References

Design, synthesis, and evaluation of gamma-phosphono diester analogues of - Design, synthesis, and evaluation of gamma-phosphono diester analogues of

Han L, Hiratake J, Kamiyama A, Sakata K. Biochemistry. 2007 Feb 6;46(5):1432-47.

Preventive effect of GGsTop, a novel and selective gamma-glutamyl transpeptidase - Preventive effect of GGsTop, a novel and selective gamma-glutamyl transpeptidase

Yamamoto S, Watanabe B, Hiratake J, Tanaka R, Ohkita M, Matsumura Y. J Pharmacol Exp Ther. 2011 Dec;339(3):945-51.