GGTI 298

• Supplier: Tocris Bioscience
• Catalog: 4452
• Prices: $185.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 1217457-86-7
• Chemical Name: N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucinemethylestertrifluoroacetatesalt
• Formula: C27H33N3O3S.CF3CO2H
• Molecular Weight: 593.66
• Purity: >95 %
• Description: CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC 50 values are 3 and > 10 μ M respectively). Causes G 0 -G 1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

Product References

Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole - Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole

Qian Y, Vogt A, Vasudevan A, Sebti SM, Hamilton AD. Bioorg Med Chem. 1998 Mar;6(3):293-9.

RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal - RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal

Patel CA, Rattan S. J Pharmacol Exp Ther. 2007 May;321(2):501-8. Epub 2007 Feb 22.