GI 254023X

• Supplier: Tocris Bioscience
• Catalog: 1922
• Prices: $165.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 260264-93-5
• Chemical Name: (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide
• Formula: C21H33N3O4
• Molecular Weight: 391.5
• Purity: >98 %
• Description: Selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17. Blocks constitutive release of IL-6R, CX3CL1 and CXCL16 in cell-based cleavage experiments. Inhibits calcium ionophore-induced betacellulin shedding in IMPE cells. Prevents E-cadherin cleavage in A549 cells.

Product References

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive - The disintegrin-like metalloproteinase ADAM10 is involved in constitutive

Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A. Blood. 2003 Aug 15;102(4):1186-95. Epub 2003 Apr 24.

Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 - Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10

Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD. Comb Chem High Throughput Screen. 2005 Mar;8(2):161-71.

The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and - The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and

Moss ML, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart PM, Gillispie PA, Stoeck A, Wildeboer D, Bartsch JW, Palmisano R, Zhou P. J Biol Chem. 2007 Dec 7;282(49):35712-21. Epub 2007 Sep 25.

A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to - A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to

Inoshima I, Inoshima N, Wilke GA, Powers ME, Frank KM, Wang Y, Bubeck Wardenburg J. Nat Med. 2011 Sep 18;17(10):1310-4.