GIT 27

• Supplier: Tocris Bioscience
• Catalog: 4165
• Prices: $109.00, $455.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 6501-72-0
• Chemical Name: 4,5-Dihydro-3-phenyl-5-isoxazoleaceticacid
• Formula: C11H11NO3
• Molecular Weight: 205.21
• Purity: >99 %
• Description: Orally active immunomodulatory agent that primarily targets macrophages. Inhibits TNF- α secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 2/6 signaling pathway. Also reduces the secretion of pro-inflammatory cytokines IL1- β , IL-10 and IFN- γ . Antidiabetogenic; prevents IL- β and IFN- γ -induced pancreatic islet cell death in vitro .

Product References

In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline - In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline

Stojanovic I, Cuzzocrea S, Mangano K, Mazzon E, Miljkovic D, Wang M, Donia M, Al Abed Y, Kim J, Nicoletti F, Stosic-Grujicic S, Claesson M. Clin Immunol. 2007 Jun;123(3):311-23. Epub 2007 Apr 20.

A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic - A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic

Stosic-Grujicic S, Cvetkovic I, Mangano K, Fresta M, Maksimovic-Ivanic D, Harhaji L, Popadic D, Momcilovic M, Miljkovic D, Kim J, Al-Abed Y, Nicoletti F. J Pharmacol Exp Ther. 2007 Mar;320(3):1038-49. Epub 2006 Dec 5.

In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression - In vitro inhibition of enterobacteria-reactive CD4+CD25- T cells and suppression

Mangano K, Sardesai N, D'Alcamo M, Libra M, Malaguarnera L, Donia M, Bendtzen K, Meroni P, Nicoletti F. Eur J Pharmacol. 2008 May 31;586(1-3):313-21.