GKA 50

• Supplier: Tocris Bioscience
• Catalog: 3270
• Prices: $255.00
• Sizes: 10 mg
• Function Type: Activator
• Cas Number: 851884-87-2
• Chemical Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylicacid
• Formula: C26H28N2O6
• Molecular Weight: 464.51
• Purity: >98 %
• Description: Potent glucokinase activator (EC 50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.

Product References

Predictive blood glucose lowering efficacy by Glucokinase activators in high fat - Predictive blood glucose lowering efficacy by Glucokinase activators in high fat

Coope GJ, Atkinson AM, Allott C, McKerrecher D, Johnstone C, Pike KG, Holme PC, Vertigan H, Gill D, Coghlan MP, Leighton B. Br J Pharmacol. 2006 Oct;149(3):328-35. Epub 2006 Aug 21.

Glucokinase activators: molecular tools for studying the physiology of - Glucokinase activators: molecular tools for studying the physiology of

Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ. Biochem Soc Trans. 2007 Nov;35(Pt 5):1208-10.