GLPG 0974

Name GLPG 0974
Supplier Tocris Bioscience
Catalog 2259
Prices $229.00
Sizes 10 mg
Function Type Antagonist
Cas Number 1391076-61-1
Chemical Name 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoicacid
Formula C25H25ClN2O4S
Molecular Weight 485
Purity >98 %
Description Potent FFA2 antagonist (IC 50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.
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Product References

Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. - Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist.

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Glucagon receptors on human islet cells contribute to glucose competence of - Glucagon receptors on human islet cells contribute to glucose competence of

Huypens P, Ling Z, Pipeleers D, Schuit F. Diabetologia. 2000 Aug;43(8):1012-9.