Glucagon-like peptide 1 (7-36) amide (human, rat)

• Supplier: Tocris Bioscience
• Catalog: 1851
• Prices: $395.00
• Sizes: 1 mg
• Cas Number: 107444-51-9
• Formula: C149H226N40O45
• Molecular Weight: 3297.67
• Description: Potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (K d = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β -cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.

Product References

Receptors for glucagon-like peptide-1(7-36) amide on rat insulinoma-derived - Receptors for glucagon-like peptide-1(7-36) amide on rat insulinoma-derived

Goke R, Conlon JM. J Endocrinol. 1988 Mar;116(3):357-62.

A role for glucagon-like peptide-1 in the central regulation of feeding. - A role for glucagon-like peptide-1 in the central regulation of feeding.

Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR. Nature. 1996 Jan 4;379(6560):69-72.

Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function. - Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function.

Perfetti R, Merkel P. Eur J Endocrinol. 2000 Dec;143(6):717-25.

Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 - Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1

Perry T, Haughey NJ, Mattson MP, Egan JM, Greig NH. J Pharmacol Exp Ther. 2002 Sep;302(3):881-8.