GlyH 101

• Supplier: Tocris Bioscience
• Catalog: 0219
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 328541-79-3
• Chemical Name: N-2-Naphthalenyl-2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]glycinehydrazide
• Formula: C19H15Br2N3O3
• Molecular Weight: 493.15
• Purity: >98 %
• Description: Reversible, voltage-dependent CFTR chloride channel blocker (K i = 4.3 μ M). Inhibits forskolin -induced hyperpolarization in nasal potential differences and inhibits cholera toxin-induced intestinal fluid secretion in mice.

Product References

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, - Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism,

Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS. J Gen Physiol. 2004 Aug;124(2):125-37.

Locating a plausible binding site for an open-channel blocker, GlyH-101, in the - Locating a plausible binding site for an open-channel blocker, GlyH-101, in the

Norimatsu Y, Ivetac A, Alexander C, O'Donnell N, Frye L, Sansom MS, Dawson DC. Mol Pharmacol. 2012 Dec;82(6):1042-55.