GM 6001

• Supplier: Tocris Bioscience
• Catalog: 3406
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 142880-36-2
• Chemical Name: (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide
• Formula: C20H28N4O4
• Molecular Weight: 388.46
• Purity: >95 %
• Description: Broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (K i = 0.4 nM).

Product References

Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas - Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas

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Leptin stimulates endothelin-1 expression via extracellular signal-regulated - Leptin stimulates endothelin-1 expression via extracellular signal-regulated

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Involvement of matrix metalloproteinase-mediated proteolysis of neural cell - Involvement of matrix metalloproteinase-mediated proteolysis of neural cell

Shichi K, Fujita-Hamabe W, Harada S, Mizoguchi H, Yamada K, Nabeshima T, Tokuyama S. J Pharmacol Exp Ther. 2011 Aug;338(2):701-10.