GN 44028

• Supplier: Tocris Bioscience
• Catalog: 5028
• Prices: $179.00, $745.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1421448-26-1
• Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
• Formula: C18N15N3O2
• Molecular Weight: 305.33
• Purity: >98 %
• Description: Potent HIF-1 α inhibitor (IC 50 = 14 nM). Inhibits hypoxia-induced HIF-1 α transcriptional activity without suppressing HIF-1 α mRNA expression, HIF-1 α protein accumulation, or HIF-1 α /HIF-1 β heterodimerization. Cytotoxic to a range of cancer cell types in vitro .

Product References

Allosteric inhibitors of Bcr-abl-dependent cell proliferation. - Allosteric inhibitors of Bcr-abl-dependent cell proliferation.

Adrian FJ, Ding Q, Sim T, Velentza A, Sloan C, Liu Y, Zhang G, Hur W, Ding S, Manley P, Mestan J, Fabbro D, Gray NS. Nat Chem Biol. 2006 Feb;2(2):95-102. Epub 2006 Jan 15.

Inhibitors of Bcr-abl... breaking new ground again. - Inhibitors of Bcr-abl... breaking new ground again.

Ohren JF, Sebolt-Leopold JS. Nat Chem Biol. 2006 Feb;2(2):63-4.

Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. - Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.

Zhang J, Adrian FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, Guo GR, Ding Q, Okram B, Choi Y, Wojciechowski A, Deng X, Liu G, Fendrich G, Strauss A, Vajpai N, Grzesiek S, Tuntland T, Liu Y, Bursulaya B, Azam M, Manley PW, Engen JR, Daley GQ, Warmuth M, Gray NS. Nature. 2010 Jan 28;463(7280):501-6.