| Name | GNF 5837 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4908 |
| Prices | $245.00, $1,005.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1033769-28-6 |
| Chemical Name | N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
| Formula | C28H21F4N5O2 |
| Molecular Weight | 535.49 |
| Purity | >98 % |
| Description | Potent pan-Trk inhibitor. Displays antiproliferative effects in cellular Ba/F3 assays (IC 50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively). Exhibits selectivity for Trk receptors over a range of kinases, with some activity at PDGFR and c-Kit (IC 50 values are 0.87 and 0.91 μ M respectively). Orally bioavailable. |
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