6'-GNTI dihydrochloride

Name 6'-GNTI dihydrochloride
Supplier Tocris Bioscience
Catalog 1282
Prices $195.00
Sizes 10 mg
Function Type Agonist
Chemical Name 6''-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5a-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinandihydrochloride
Formula C27H29N5O3.2HCl
Molecular Weight 544.48
Purity >97 %
Description Selective κ / δ -opioid heterodimer receptor agonist (EC 50 = 39.8, 112.5 and > 1000 nM for κ / δ , κ / μ and δ / μ respectively) that has no effect on opioid receptor homodimers (EC 50 > 1000 nM). Displays tissue-specific analgesic effects in vitro .
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Product References

Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by - Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by

Sharma SK, Jones RM, Metzger TG, Ferguson DM, Portoghese PS. J Med Chem. 2001 Jun 21;44(13):2073-9.

6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased kappa-opioid receptor - 6'-Guanidinonaltrindole (6'-GNTI) is a G protein-biased kappa-opioid receptor

Rives ML, Rossillo M, Liu-Chen LY, Javitch JA. J Biol Chem. 2012 Aug 3;287(32):27050-4.