Go 6976

Name Go 6976
Supplier Tocris Bioscience
Catalog 2962
Prices $219.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 136194-77-9
Chemical Name 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
Formula C24H18N4O
Molecular Weight 378.43
Purity >98 %
Description Potent protein kinase C (PKC) inhibitor (IC 50 = 7.9 nM). Discriminates between Ca 2+ -dependent and -independent isoforms of PKC in vitro ; selectively inhibits PKC α and PKC β 1 (IC 50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKC δ , - ε , or - ζ (IC 50 > 3 μ M). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC 50 values are 5, 30, 130 and 370 nM respectively), PKC μ (PKD1) and the mitotic spindle checkpoint.
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Product References

Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. - Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976.

Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C. J Biol Chem. 1993 May 5;268(13):9194-7.

Immunological demonstration of protein kinase C mu in murine tissues and various - Immunological demonstration of protein kinase C mu in murine tissues and various

Rennecke J, Johannes FJ, Richter KH, Kittstein W, Marks F, Gschwendt M. Eur J Biochem. 1996 Dec 1;242(2):428-32.

Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. - Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.

Behrens MM, Strasser U, Choi DW. J Neurochem. 1999 Mar;72(3):919-24.

Go6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with - Go6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with

Grandage VL, Everington T, Linch DC, Khwaja A. Br J Haematol. 2006 Nov;135(3):303-16. Epub 2006 Sep 4.

Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole - Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole

Stolz A, Vogel C, Schneider V, Ertych N, Kienitz A, Yu H, Bastians H. Cancer Res. 2009 May 1;69(9):3874-83.