GPBAR-A

Name GPBAR-A
Supplier Tocris Bioscience
Catalog 2678
Prices $219.00, $905.00
Sizes 10 mg, 50 mg
Function Type Agonist
Cas Number 877052-79-4
Chemical Name 4-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(2-fluorophenyl)-4,5-dihydro-pyrido[3,2-f]-1,4-oxazepin-3(2H)-one
Formula C23H15F7N2O2
Molecular Weight 484.37
Purity >98 %
Description GPBA receptor agonist. Upregulates GLP-1 secretion from intestinal cultures. Increases MQAE-fluorescence suggesting a decrease in intracellular chloride concentration in gallbladder epithelial cells.
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Product References

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of - The membrane-bound bile acid receptor TGR5 is localized in the epithelium of

Keitel V, Cupisti K, Ullmer C, Knoefel WT, Kubitz R, Haussinger D. Hepatology. 2009 Sep;50(3):861-70.

Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 - Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1

Parker HE, Wallis K, le Roux CW, Wong KY, Reimann F, Gribble FM. Br J Pharmacol. 2012 Jan;165(2):414-23.