GR 113808

• Supplier: Tocris Bioscience
• Catalog: 1931
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 144625-51-4
• Chemical Name: 1-methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methylester
• Formula: C19H27N3O4S
• Molecular Weight: 393.5
• Purity: >98 %
• Description: Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.

Product References

Dopamine D3 receptors are not involved in the induction of c-fos mRNA by - Dopamine D3 receptors are not involved in the induction of c-fos mRNA by

Hurley MJ, Stubbs CM, Jenner P, Marsden CD. Eur J Pharmacol. 1996 Dec 30;318(2-3):283-93.

A comparative in vitro and in vivo pharmacological characterization of the novel - A comparative in vitro and in vivo pharmacological characterization of the novel

Audinot V, Newman-Tancredi A, Gobert A, Rivet JM, Brocco M, Lejeune F, Gluck L, Desposte I, Bervoets K, Dekeyne A, Millan MJ. J Pharmacol Exp Ther. 1998 Oct;287(1):187-97.