GR 125487 sulfamate

Name GR 125487 sulfamate
Supplier Tocris Bioscience
Catalog 1322
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 859502-43-5
Chemical Name 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylatesulfamate
Formula C19H26FN3O5S.H2NSO3H
Molecular Weight 524.58
Purity >97 %
Description Potent and selective 5-HT 4 receptor antagonist (K i = 0.19 nM for porcine 5-HT 4 ). Centrally active following systemic administration in vivo .
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Product References

Identification of serotonin 5-HT4 recognition sites in the porcine caudate - Identification of serotonin 5-HT4 recognition sites in the porcine caudate

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Role of 5-HT4 receptors in the mouse passive avoidance test. - Role of 5-HT4 receptors in the mouse passive avoidance test.

Galeotti N, Ghelardini C, Bartolini A. J Pharmacol Exp Ther. 1998 Sep;286(3):1115-21.

Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the - Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the

Horikoshi K, Yokoyama T, Kishibayashi N, Ohmori K, Ishii A, Karasawa A. Jpn J Pharmacol. 2001 Jan;85(1):70-4.