GR 144053 trihydrochloride

Name GR 144053 trihydrochloride
Supplier Tocris Bioscience
Catalog 0896
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 1215333-48-4
Chemical Name 4-[4-[4-(Aminoiminomethyl)phenyl]-1-piperazinyl]-1-piperidineaceticacidtrihydrochloride
Formula C18H27N5O2.3HCl
Molecular Weight 454.83
Purity >99 %
Description A potent and selective platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist (IC 50 = 37 nM). Orally active and highly effective at inhibiting thrombus formation in vivo .
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Product References

Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists: - Orally active non-peptide fibrinogen receptor (GpIIb/IIIa) antagonists:

Eldred CD, Evans B, Hindley S, Judkins BD, Kelly HA, Kitchin J, Lumley P, Porter B, Ross BC, Smith KJ, et al.. J Med Chem. 1994 Nov 11;37(23):3882-5.

GR144053, a fibrinogen receptor antagonist, enhances the suppression of neointima - GR144053, a fibrinogen receptor antagonist, enhances the suppression of neointima

Matsuno H, Kozawa O, Niwa M, Kaida T, Hayashi H, Uematsu T. Br J Pharmacol. 1997 Nov;122(6):1099-104.

Comparative antiplatelet effects of aspirin, vapiprost and GR144053, a GPIIb/IIIa - Comparative antiplatelet effects of aspirin, vapiprost and GR144053, a GPIIb/IIIa

Matsuno H, Kozawa O, Nagashima S, Kanamaru M, Uematsu T. Br J Pharmacol. 1999 Jul;127(5):1129-34.