GR 159897

Name GR 159897
Supplier Tocris Bioscience
Catalog 1263
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 158848-32-9
Chemical Name 5-Fluoro-3-[2-[4-methoxy-4-[[(R)-phenylsulphinyl]methyl]-1-piperidinyl]ethyl]-1H-indole
Formula C23H27FN2O2S
Molecular Weight 414.54
Purity >97 %
Description A potent, selective, non-peptide, orally active neurokinin NK 2 receptor antagonist. Competes for binding of [ 3 H]GR100679 to hNK 2 -transfected CHO cells with a pK i of 9.5. Inhibits NK 2 receptor-mediated contraction of guinea pig trachea with a pA 2 of 8.7. Anxiolytic in vivo .
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Product References

GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. - GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors.

Beresford IJ, Sheldrick RL, Ball DI, Turpin MP, Walsh DM, Hawcock AB, Coleman RA, Hagan RM, Tyers MB. Eur J Pharmacol. 1995 Jan 16;272(2-3):241-8.

The anxiolytic-like activity of GR159897, a non-peptide NK2 receptor antagonist, - The anxiolytic-like activity of GR159897, a non-peptide NK2 receptor antagonist,

Walsh DM, Stratton SC, Harvey FJ, Beresford IJ, Hagan RM. Psychopharmacology (Berl). 1995 Sep;121(2):186-91.