GR 55562 dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0864
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 159533-25-2
• Chemical Name: 3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamidedihydrochloride
• Formula: C23H25N3O2.2HCl
• Molecular Weight: 448.39
• Purity: >98 %
• Description: A selective competitive 5-HT 1B (5-HT 1D β ) silent antagonist with pK B values of 7.3 and 6.3 for human cloned 5-HT 1B and 5-HT 1D receptors respectively and only weak binding at a number of other 5-HT subtypes.

Product References

The activity of 5-HT1D receptor ligands at cloned human 5-HT1D alpha and 5-HT1D - The activity of 5-HT1D receptor ligands at cloned human 5-HT1D alpha and 5-HT1D

Walsh DM, Beattie DT, Connor HE. Eur J Pharmacol. 1995 Dec 4;287(1):79-84.

Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary - Evidence for 5-HT1-like receptor-mediated vasoconstriction in human pulmonary

MacLean MR, Clayton RA, Templeton AG, Morecroft I. Br J Pharmacol. 1996 Sep;119(2):277-82.