GRI 977143

• Supplier: Tocris Bioscience
• Catalog: 1172
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 325850-81-5
• Chemical Name: 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoicacid
• Formula: C22H17NO4S
• Molecular Weight: 391.44
• Purity: >98 %
• Description: Selective lysophosphatidic acid 2 (LPA 2 ) receptor non-lipid agonist (EC 50 = 3.3 μ M). Does not activate other LPA GPCRs at concentrations up to 10 μ M. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.

Product References

Virtual screening for LPA2-specific agonists identifies a nonlipid compound with - Virtual screening for LPA2-specific agonists identifies a nonlipid compound with

Kiss GN, Fells JI, Gupte R, Lee SC, Liu J, Nusser N, Lim KG, Ray RM, Lin FT, Parrill AL, Sumegi B, Miller DD, Tigyi G. Mol Pharmacol. 2012 Dec;82(6):1162-73.

Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. - Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.

Kiss GN, Lee SC, Fells JI, Liu J, Valentine WJ, Fujiwara Y, Thompson KE, Yates CR, Sumegi B, Tigyi G. Biochim Biophys Acta. 2013 Jan;1831(1):117-25.