GRP (human)

• Supplier: Tocris Bioscience
• Catalog: 1828
• Prices: $259.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 93755-85-2
• Formula: C130H204N38O31S2
• Molecular Weight: 2859.4
• Description: Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo . Also involved in mitogenesis, and GI tract and appetite regulation.

Product References

Expression and characterization of cloned human bombesin receptors. - Expression and characterization of cloned human bombesin receptors.

Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT. Mol Pharmacol. 1995 Jan;47(1):10-20.

Bombesin receptors in the brain. - Bombesin receptors in the brain.

Woodruff GN, Hall MD, Reynolds T, Pinnock RD. Ann N Y Acad Sci. 1996 Mar 22;780:223-43.

Identification of a signaling network in lateral nucleus of amygdala important - Identification of a signaling network in lateral nucleus of amygdala important

Shumyatsky GP, Tsvetkov E, Malleret G, Vronskaya S, Hatton M, Hampton L, Battey JF, Dulac C, Kandel ER, Bolshakov VY. Cell. 2002 Dec 13;111(6):905-18.

Neurobiology: Fear thou not. - Neurobiology: Fear thou not.

Dudai Y. Nature. 2003 Jan 23;421(6921):325-7.