GS 143

• Supplier: Tocris Bioscience
• Catalog: 1788
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 916232-21-8
• Chemical Name: 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoicacid
• Formula: C28H19FN2O4
• Molecular Weight: 466.46
• Purity: >98 %
• Description: β -TrCP1 ligase inhibitor. Inhibits I κ B α ubiquitination (IC 50 = 5.2 μ M) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NF κ B expression, inflammation and mucus production in airways of OVA-sensitized mice.

Product References

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and - N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and

Urwyler S, Pozza MF, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, Koller M, Kaupmann K. J Pharmacol Exp Ther. 2003 Oct;307(1):322-30. Epub 2003 Sep 3.

Behavioral characterization of the novel GABAB receptor-positive modulator - Behavioral characterization of the novel GABAB receptor-positive modulator

Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP. J Pharmacol Exp Ther. 2004 Sep;310(3):952-63. Epub 2004 Apr 27.

GABAB receptor-positive modulation-induced blockade of the rewarding properties - GABAB receptor-positive modulation-induced blockade of the rewarding properties

Mombereau C, Lhuillier L, Kaupmann K, Cryan JF. J Pharmacol Exp Ther. 2007 Apr;321(1):172-7. Epub 2007 Jan 10.