| Name | GSK 1363089 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4026 |
| Prices | $165.00, $695.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 849217-64-7 |
| Chemical Name | N-[3-Fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Formula | C34H34F2N4O6 |
| Molecular Weight | 632.65 |
| Purity | >98 % |
| Description | Potent inhibitor of MET, VEGFR2, Ron and AXL (IC 50 values are 0.4, 0.9, 3 and 11 nM, respectively). Also potently inhibits Tie-2, Flt-1, Flt-3, Flt-4, KIT, PDGFR α and PDGFR β . Inhibits migration and invasion of B16F10 melanoma cells in vitro . Suppresses B16F10 tumor growth and metastasis in mice. Orally available. |
| Supplier Page | Shop |
Martin C, Passilly-Degrace P, Chevrot M, Ancel D, Sparks SM, Drucker DJ, Besnard P. J Lipid Res. 2012 Nov;53(11):2256-65.
Sparks SM, Chen G, Collins JL, Danger D, Dock ST, Jayawickreme C, Jenkinson S, Laudeman C, Leesnitzer MA, Liang X, Maloney P, McCoy DC, Moncol D, Rash V, Rimele T, Vulimiri P, Way JM, Ross S. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3.