| Name | GSK 1562590 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5257 |
| Prices | $255.00, $1,045.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 1003878-07-6 |
| Chemical Name | N-[(1R)-1-[3'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-4H-1,4-benzoxazine-4-acetamidehydrochloride |
| Formula | C30H30Cl2N4O4.HCl |
| Molecular Weight | 617.95 |
| Purity | >98 % |
| Description | High affinity and selective urotensin II (UT) receptor antagonist (pK i values are 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors respectively). Exhibits selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. Supresses human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo . Inhibits the hU-II-induced increase in mean blood pressure in vivo . Orally active. |
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