| Name | GSK 1838705 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5110 |
| Prices | $245.00, $1,005.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1116235-97-2 |
| Chemical Name | 2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide |
| Formula | C27H29FN8O3 |
| Molecular Weight | 532.57 |
| Purity | >98 % |
| Description | Potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor (IC 50 values are 1.6 and 2 nM, respectively). Also inhibits anaplastic lymphoma kinase (ALK) (IC 50 = 0.5 nM). Displays > 800-fold selectivity for IR, IGFR1 and ALK over a panel of 44 kinases including JNK. Blocks proliferation of cancer cell lines in vitro , and causes complete regression of ALK-dependent tumors in vivo . Orally bioavailable. |
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Gao M, Liang J, Lu Y, Guo H, German P, Bai S, Jonasch E, Yang X, Mills GB, Ding Z. Oncogene. 2014 Feb 6;33(6):745-55.