| Name | GSK 2837808A |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5140 |
| Prices | $279.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1445879-21-9 |
| Chemical Name | 3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoicacid |
| Formula | C31H25F2N5O7S |
| Molecular Weight | 649.62 |
| Purity | >98 % |
| Description | Potent, selective lactate dehydrogenase A (LDHA) inhibitor (IC 50 values are 1.9 and 14 nM for LDHA and LDHB respectively). Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. Inhibits proliferation and induces apoptosis in Snu398 cells. Cell permeable. |
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Billiard J, Dennison JB, Briand J, Annan RS, Chai D, Colon M, Dodson CS, Gilbert SA, Greshock J, Jing J, Lu H, McSurdy-Freed JE, Orband-Miller LA, Mills GB, Quinn CJ, Schneck JL, Scott GF, Shaw AN, Waitt GM, Wooster RF, Duffy KJ. Cancer Metab. 2013 Sep 6;1(1):19.
Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M 2nd, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P. Cell Metab. 2014 May 6;19(5):795-809.