| Name | GSK 429286 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3663 |
| Prices | $109.00, $255.00, $1,045.00 |
| Sizes | 1 mg, 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 864082-47-3 |
| Chemical Name | 4-[4-(Trifluoromethyl)phenyl]-N-(6-Fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide |
| Formula | C21H16F4N4O2 |
| Molecular Weight | 432.37 |
| Purity | >97 % |
| Description | Selective Rho-kinase inhibitor (IC 50 values are 14, 780 and 1940 nM for ROCK1, RSK and p70S6K respectively). Reverses adrenalin-induced contraction of the rat aortic ring (IC 50 = 190 nM) and causes a dose-dependent decrease in mean arterial blood pressure in spontaneous hypertensive rats. Orally active. |
| Supplier Page | Shop |
Goodman KB, Cui H, Dowdell SE, Gaitanopoulos DE, Ivy RL, Sehon CA, Stavenger RA, Wang GZ, Viet AQ, Xu W, Ye G, Semus SF, Evans C, Fries HE, Jolivette LJ, Kirkpatrick RB, Dul E, Khandekar SS, Yi T, Jung DK, Wright LL, Smith GK, Behm DJ, Bentley R, Doe CP, Hu E, Lee D. J Med Chem. 2007 Jan 11;50(1):6-9.
Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Biochem J. 2009 Oct 23;424(1):47-60.