GSK 4716

• Supplier: Tocris Bioscience
• Catalog: 3726
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 101574-65-6
• Chemical Name: 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
• Formula: C17H18N2O2
• Molecular Weight: 282.34
• Purity: >99 %
• Description: Selective agonist at estrogen-related receptors ERR β and ERR γ . Displays selectivity over ERR α and the classical estrogen receptors.

Product References

Identification and structure-activity relationship of phenolic acyl hydrazones as - Identification and structure-activity relationship of phenolic acyl hydrazones as

Zuercher WJ, Gaillard S, Orband-Miller LA, Chao EY, Shearer BG, Jones DG, Miller AB, Collins JL, McDonnell DP, Willson TM. J Med Chem. 2005 May 5;48(9):3107-9.

Estrogen-related receptors as emerging targets in cancer and metabolic disorders. - Estrogen-related receptors as emerging targets in cancer and metabolic disorders.

Ariazi EA, Jordan VC. Curr Top Med Chem. 2006;6(3):203-15.

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding - X-ray crystal structures of the estrogen-related receptor-gamma ligand binding

Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT. J Biol Chem. 2006 Dec 8;281(49):37773-81. Epub 2006 Sep 21.