| Name | GSK 650394 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5385 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 890842-28-1 |
| Chemical Name | 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoicacid |
| Formula | C25H22N2O2 |
| Molecular Weight | 382.45 |
| Purity | >97 % |
| Description | Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC 50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC 50 ~ 1 μ M). |
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Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, Norris JD, McDonnell DP. Cancer Res. 2008 Sep 15;68(18):7475-83.
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