GSK J2

• Supplier: Tocris Bioscience
• Catalog: 4593
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Cas Number: 1394854-52-4
• Chemical Name: N-[2-(3-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanineethylester
• Formula: C22H23N5O2
• Molecular Weight: 389.45
• Purity: >98 %
• Description: Inactive control of GSK J1 (Cat No.4593) (IC 50 > 100 μ M for inhibition of JMJD3/UTX). Cell permeable ester derivative, GSK J5 (Cat. No. 4689), also available.

Product References

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory - A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM. Nature. 2012 Aug 16;488(7411):404-8.