GSK J4

• Supplier: Tocris Bioscience
• Catalog: 4688
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1373423-53-0
• Chemical Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanineethylester
• Formula: C24H27N5O2
• Molecular Weight: 417.5
• Purity: >99 %
• Description: Histone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC 50 = 9 μ M for the inhibition of TNF α release). Cell permeable. Ethyl ester derivative of GSK J1 (Cat. No. 4593).

Product References

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory - A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory

Kruidenier L, Chung CW, Cheng Z, Liddle J, Che K, Joberty G, Bantscheff M, Bountra C, Bridges A, Diallo H, Eberhard D, Hutchinson S, Jones E, Katso R, Leveridge M, Mander PK, Mosley J, Ramirez-Molina C, Rowland P, Schofield CJ, Sheppard RJ, Smith JE, Swales C, Tanner R, Thomas P, Tumber A, Drewes G, Oppermann U, Patel DJ, Lee K, Wilson DM. Nature. 2012 Aug 16;488(7411):404-8.

Inhibition of demethylases by GSK-J1/J4. - Inhibition of demethylases by GSK-J1/J4.

Heinemann B, Nielsen JM, Hudlebusch HR, Lees MJ, Larsen DV, Boesen T, Labelle M, Gerlach LO, Birk P, Helin K. Nature. 2014 Oct 2;514(7520):E1-2.