GT 2016

• Supplier: Tocris Bioscience
• Catalog: 4912
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 152241-24-2
• Chemical Name: 5-Cyclohexyl-1-[4-(1H-imidazol-5-yl)-1-piperidinyl]-1-pentanone
• Formula: C19H31N3O
• Molecular Weight: 317.47
• Purity: >98 %
• Description: High affinity H 3 receptor antagonist (K i = 43.8 nM). Displays selectivity against H 1 and H 2 receptors (IC 50 >10 μ M). Increases the release of histamine in the cerebral cortex. Displays no activity at histamine methyltransferase in vitro at concentrations up to 3 μ M. Brain penetrant.

Product References

Pharmacological characterization of GT-2016, a non-thiourea-containing histamine - Pharmacological characterization of GT-2016, a non-thiourea-containing histamine

Tedford CE, Yates SL, Pawlowski GP, Nalwalk JW, Hough LB, Khan MA, Phillips JG, Durant GJ, Frederickson RC. J Pharmacol Exp Ther. 1995 Nov;275(2):598-604.

Development of trans-2-[1H-imidazol-4-yl] cyclopropane derivatives as new - Development of trans-2-[1H-imidazol-4-yl] cyclopropane derivatives as new

Tedford CE, Phillips JG, Gregory R, Pawlowski GP, Fadnis L, Khan MA, Ali SM, Handley MK, Yates SL. J Pharmacol Exp Ther. 1999 May;289(2):1160-8.

Identification and pharmacological characterization of a series of new - Identification and pharmacological characterization of a series of new

Yates SL, Phillips JG, Gregory R, Pawlowski GP, Fadnis L, Khan MA, Ali SM, Tedford CE. J Pharmacol Exp Ther. 1999 May;289(2):1151-9.