Guggulsterone

• Supplier: Tocris Bioscience
• Catalog: 4742
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Cas Number: 95975-55-6
• Chemical Name: Pregna-4,17(20)-diene-3,16-dione
• Formula: C21H28O2
• Molecular Weight: 312.45
• Purity: >99 %
• Description: Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).

Product References

The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor - The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor

Burris TP, Montrose C, Houck KA, Osborne HE, Bocchinfuso WP, Yaden BC, Cheng CC, Zink RW, Barr RJ, Hepler CD, Krishnan V, Bullock HA, Burris LL, Galvin RJ, Bramlett K, Stayrook KR. Mol Pharmacol. 2005 Mar;67(3):948-54. Epub 2004 Dec 15.

Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a - Is antagonism of E/Z-guggulsterone at the farnesoid X receptor mediated by a

Meyer U, Costantino G, Macchiarulo A, Pellicciari R. J Med Chem. 2005 Nov 3;48(22):6948-55.