| Name | Z -Guggulsterone |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2013 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 39025-23-5 |
| Chemical Name | (Z)-Pregna-4,17(20)-diene-3,16-dione |
| Formula | C21H28O2 |
| Molecular Weight | 312.45 |
| Purity | >98 % |
| Description | Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K i values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K i = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signaling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo . More active isomer of guggulsterone (Cat. No. 2013). |
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