| Name | GW 0742 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0234 |
| Prices | $195.00, $805.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 317318-84-6 |
| Chemical Name | [4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]aceticacid |
| Formula | C21H17F4NO3S2 |
| Molecular Weight | 471.49 |
| Purity | >98 % |
| Description | Potent and highly selective PPAR δ agonist. EC 50 values are 0.001, 1.1 and 2 μ M for transactivation of human PPAR δ , - α , and - γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes. |
| Supplier Page | Shop |
Sznaidman ML, Haffner CD, Maloney PR, Fivush A, Chao E, Goreham D, Sierra ML, LeGrumelec C, Xu HE, Montana VG, Lambert MH, Willson TM, Oliver WR Jr, Sternbach DD. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21.
Smith SA, Monteith GR, Robinson JA, Venkata NG, May FJ, Roberts-Thomson SJ. J Neurosci Res. 2004 Jul 15;77(2):240-9.