| Name | GW 2580 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1664 |
| Prices | $129.00, $535.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 870483-87-7 |
| Chemical Name | 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine |
| Formula | C20H22N4O3 |
| Molecular Weight | 366.41 |
| Purity | >99 % |
| Description | Potent and selective cFMS kinase inhibitor (IC 50 = 0.06 μ M). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro . Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable. |
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Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA, Willson TM. J Med Chem. 2002 May 9;45(10):1963-6.
Leik CE, Carson NL, Hennan JK, Basso MD, Liu QY, Crandall DL, Nambi P. Br J Pharmacol. 2007 Jun;151(4):450-6. Epub 2007 Apr 10.