GW 4064

• Supplier: Tocris Bioscience
• Catalog: 2374
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 278779-30-9
• Chemical Name: 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoicacid
• Formula: C28H22Cl3NO4
• Molecular Weight: 542.84
• Purity: >97 %
• Description: Selective, non-steroidal farnesoid X receptor (FXR) agonist (EC 50 = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μ M. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes.

Product References

Identification of a chemical tool for the orphan nuclear receptor FXR. - Identification of a chemical tool for the orphan nuclear receptor FXR.

Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, Plunket KD, Creech KL, Moore LB, Wilson JG, Lewis MC, Jones SA, Willson TM. J Med Chem. 2000 Aug 10;43(16):2971-4.

The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity - The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity

Cariou B, van Harmelen K, Duran-Sandoval D, van Dijk TH, Grefhorst A, Abdelkarim M, Caron S, Torpier G, Fruchart JC, Gonzalez FJ, Kuipers F, Staels B. J Biol Chem. 2006 Apr 21;281(16):11039-49. Epub 2006 Jan 30.

Nutrient-sensing nuclear receptors coordinate autophagy. - Nutrient-sensing nuclear receptors coordinate autophagy.

Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD. Nature. 2014 Dec 4;516(7529):112-5.