GW 5074

• Supplier: Tocris Bioscience
• Catalog: 5674
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 220904-83-6
• Chemical Name: 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one
• Formula: C15H8Br2INO2
• Molecular Weight: 520.94
• Purity: >98 %
• Description: Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC 50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.

Product References

The discovery of potent cRaf1 kinase inhibitors. - The discovery of potent cRaf1 kinase inhibitors.

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Involvement of Raf-1 in chronic delta-opioid receptor agonist-mediated adenylyl - Involvement of Raf-1 in chronic delta-opioid receptor agonist-mediated adenylyl

Varga EV, Rubenzik M, Grife V, Sugiyama M, Stropova D, Roeske WR, Yamamura HI. Eur J Pharmacol. 2002 Sep 6;451(1):101-2.

VEGF increases endothelial permeability by separate signaling pathways involving - VEGF increases endothelial permeability by separate signaling pathways involving

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Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of - Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of

Chen HM, Wang L, D'Mello SR. J Neurochem. 2008 May;105(4):1300-12.