| Name | GW 583340 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4311 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1173023-85-2 |
| Chemical Name | N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride |
| Formula | C28H25ClFN5O3S2.2HCl |
| Molecular Weight | 671.03 |
| Purity | >97 % |
| Description | Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC 50 values are 0.01 and 0.014 μ M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC 50 values are 0.11 μ M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μ M for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration. |
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