| Name | GW 627368 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2239 |
| Prices | $245.00, $1,005.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 439288-66-1 |
| Chemical Name | 4-(4-,9-Diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)benzeneacetamide |
| Formula | C30H28N2O6S |
| Molecular Weight | 544.62 |
| Purity | >98 % |
| Description | Selective prostanoid EP 4 receptor competitive antagonist with additional affinity at TP receptors (pK i values are 7.0 and 6.8 in competition radioligand bioassays). Affinity for all other prostanoid receptors is < 5.3. Inhibits U-46619 induced human platelet aggregation. |
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Jones RL, Chan KM. Prostaglandins Leukot Essent Fatty Acids. 2005 Apr;72(4):289-99.
Wilson RJ, Giblin GM, Roomans S, Rhodes SA, Cartwright KA, Shield VJ, Brown J, Wise A, Chowdhury J, Pritchard S, Coote J, Noel LS, Kenakin T, Burns-Kurtis CL, Morrison V, Gray DW, Giles H. Br J Pharmacol. 2006 Jun;148(3):326-39.