GW 6471

• Supplier: Tocris Bioscience
• Catalog: 4668
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 880635-03-0
• Chemical Name: N-((2S)-2-(((1Z)-1-Methyl-3-oxo-3-(4-(trifluoromethyl)phenyl)prop-1-enyl)amino)-3-(4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)phenyl)propyl)propanamide
• Formula: C35H36F3N3O4
• Molecular Weight: 619.67
• Purity: >98 %
• Description: PPAR α antagonist (IC 50 = 0.24 μ M). Enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMRT and NCoR.

Product References

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by - Structural basis for antagonist-mediated recruitment of nuclear co-repressors by

Xu HE, Stanley TB, Montana VG, Lambert MH, Shearer BG, Cobb JE, McKee DD, Galardi CM, Plunket KD, Nolte RT, Parks DJ, Moore JT, Kliewer SA, Willson TM, Stimmel JB. Nature. 2002 Feb 14;415(6873):813-7.

An innovative method to study target protein-drug interactions by mass - An innovative method to study target protein-drug interactions by mass

Muller MQ, de Koning LJ, Schmidt A, Ihling C, Syha Y, Rau O, Mechtler K, Schubert-Zsilavecz M, Sinz A. J Med Chem. 2009 May 14;52(9):2875-9.