GW 7647

• Supplier: Tocris Bioscience
• Catalog: 4618
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 265129-71-3
• Chemical Name: 2-[[4-[2-[[(Cyclohexylamino)carbonyl](4-cyclohexylbutyl)amino]ethyl]phenyl]thio]-2-methylpropanoicacid
• Formula: C29H46N2O3S
• Molecular Weight: 502.75
• Purity: >99 %
• Description: Potent and highly selective PPAR α agonist (EC 50 values are 6, 1100 and 6200 nM for human PPAR α , PPAR γ and PPAR δ receptors respectively). Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro . Has lipid-lowering effects following oral administration in vivo . Reduces NO production in macrophages; exhibits anti-inflammatory properties.

Product References

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Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization - Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization

Muoio DM, Way JM, Tanner CJ, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, Dohm GL. Diabetes. 2002 Apr;51(4):901-9.

PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation - PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation

Paukkeri EL, Leppanen T, Sareila O, Vuolteenaho K, Kankaanranta H, Moilanen E. Br J Pharmacol. 2007 Dec;152(7):1081-91. Epub 2007 Sep 24.