GW 788388

• Supplier: Tocris Bioscience
• Catalog: 1677
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 452342-67-5
• Chemical Name: 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide
• Formula: C25H23N5O2
• Molecular Weight: 425.48
• Purity: >98 %
• Description: Potent inhibitor of transforming growth factor- β type I receptor (ALK5) (IC 50 values are 18 and 93 nM for ALK5 binding and for TGF- β cellular assay respectively). Inhibits esophageal squamous cell carcinoma (ESCC)-induced neoangiogenesis. Orally active.

Product References

Discovery of - Discovery of

Gellibert F, de Gouville AC, Woolven J, Mathews N, Nguyen VL, Bertho-Ruault C, Patikis A, Grygielko ET, Laping NJ, Huet S. J Med Chem. 2006 Apr 6;49(7):2210-21.

The essential role of fibroblasts in esophageal squamous cell carcinoma-induced - The essential role of fibroblasts in esophageal squamous cell carcinoma-induced

Noma K, Smalley KS, Lioni M, Naomoto Y, Tanaka N, El-Deiry W, King AJ, Nakagawa H, Herlyn M. Gastroenterology. 2008 Jun;134(7):1981-93.

Targeted inhibition of activin receptor-like kinase 5 signaling attenuates - Targeted inhibition of activin receptor-like kinase 5 signaling attenuates

Tan SM, Zhang Y, Connelly KA, Gilbert RE, Kelly DJ. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1415-25. doi: