GW 791343 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3264
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 309712-55-8
• Chemical Name: 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamidetrihydrochloride
• Formula: C20H24F2N4O.3HCl
• Molecular Weight: 483.81
• Purity: >99 %
• Description: P2X 7 allosteric modulator. Exhibits species-specific activity; acts as a negative allosteric modulator of human P2X 7 (pIC 50 = 6.9 - 7.2) and a positive allosteric modulator of rat P2X 7 .

Product References

Negative and positive allosteric modulators of the P2X(7) receptor. - Negative and positive allosteric modulators of the P2X(7) receptor.

Michel AD, Chambers LJ, Walter DS. Br J Pharmacol. 2008 Feb;153(4):737-50. Epub 2007 Dec 10.

Identification of regions of the P2X(7) receptor that contribute to human and rat - Identification of regions of the P2X(7) receptor that contribute to human and rat

Michel AD, Clay WC, Ng SW, Roman S, Thompson K, Condreay JP, Hall M, Holbrook J, Livermore D, Senger S. Br J Pharmacol. 2008 Nov;155(5):738-51.