| Name | GW 843682X |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4242 |
| Prices | $95.00, $199.00, $825.00 |
| Sizes | 1 mg, 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 660868-91-7 |
| Chemical Name | 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide |
| Formula | C22H18F3N3O4S |
| Molecular Weight | 477.46 |
| Purity | >98 % |
| Description | Selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC 50 values are 2.2 and 9.1 nM respectively). Displays > 100-fold selectivity over ~30 other kinases tested including cdk1 and cdk2. Inhibits proliferation of most tumor cells in vitro and is selective over normal diploid fibroblasts. |
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